Full Professor of Medicinal Chemistry; Faculty of Pharmacy (Biotechnology Course), University of Pavia, Italy
1990 Degree in Chimica e Tecnologia Farmaceutiche (110/110 cum laude), University of Pavia, Italy. Thesis: “Synthesis and evaluation of the antimicrobic activity of fluoro substituted dithiobisbenzamides and benzoisothiazolones”, Tutor: Prof. G. Pagani, Department of Pharmaceutical Chemistry, University of Pavia, Italy.
1992 Master in Chemical Synthesis, (86/100), Politecnico of Milano, Italy. Thesis: “Use of enzymes in organic chemistry”, Tutor: Prof. C. Fuganti, Department of Organic Chemistry, Politecnico of Milano, Italy.
1997 Ph.D. in Chimica e Tecnologia Farmaceutiche, University of Pavia, Italy. Thesis: “New methodologies for the kinetically controlled synthesis of Ampicillin, Cefazolin and Cefamandole, catalyzed by penicillin acylases”.

Design and preparation of efficient biocatalyst by mutagenesis and immobilization of enzymes
- Acylases
- Lipases
- Esterases
- Nucleoside Phosphorylase
- Kinases
Enzymatic synthesis of drugs: development of new processes
- Synthesis of -lactamic antibiotics catalyzed by immobilized penicillin acylases
- Resolution of racemic mixtures by enzymatic catalysts
- Selective protection and deprotection of sugars catalyzed by immobilized lipases and synthesis of oligosaccharides
- Nucleosides synthesis by enzymatic transglycosylation catalyzed by Uridine Phosphorylase and Purine Nucleoside Phosphorylase
Pharmaceutical Chemistry
-study of neo-glycoproteins as potential vaccines

Marco Filice, Jose M. Palomo, Paolo Bonomi, Teodora Bavaro, Roberto Fernandez-Lafuente, Jose M. Guisan, and Marco Terreni “Preparation of linear oligosaccharides by a simple monoprotective chemo-enzymatic approach” Tetrahedron 64, 9286-9292 (2008).

Marco Filice, Teodora Bavaro, Roberto Fernandez-Lafuente, Massimo Pregnolato, Jose M Guisa, Jose M Palomo and Marco Terreni “Chemo-Biocatalytic Regioselective One Pot Synthesis of Different Deprotected Monosaccharides” Catalysis Today; 140 (1-2), 11-18 (2009)

Immacolata Serra, Davide A. Cecchini, Daniela Ubiali, Elena M. Manazza, Alessandra M. Albertini, Marco Terreni “Coupling of site-directed mutagenesis and immobilization for the rational design of more efficient biocatalysts. The case of immobilized 3G3K PGA from E. coli. Eur. J. of Org. Chem. 9, 1384-1398 (2009)

Bonomi Paolo, Cairoli Paola, Ubiali Daniela, Morelli Carlo F., Filice Marco, Nieto Ines, Pregnolato Massimo, Manitto Paolo, Terreni Marco, Speranza Giovanna; “Enzymatic resolution of 5-hydroxy- and 8-hydroxy-2-tetralols using immobilized lipases” Tetrahedron Asymmetry. 20 467-472 (2009)

Bavaro Teodora, Rocchietti Silvia, Ubiali Daniela, Filice Marco, Terreni Marco, Pregnolato Massimo.”A Versatile Synthesis of 5'-Functionalized Nucleosides Through Regioselective Enzymatic Hydrolysis of Their Peracetylated Precursors” Eur. J. of Org. Chem. 12, 1967-1975 (2009)

Marco Filice, Renzo Vanna, Marco Terreni, Jose M. Guisan, e Jose M. Palomo “Lipase-Catalyzed Regioselective One-Step Synthesis of Penta-O-acetyl-3-hydroxylactal” Eur. J. of Org. Chem. 12, 3327-3329 (2009)

Teodora Bavaro, Daniela Ubiali, Stefania Brocca, Silvia Rocchietti, Ines Nieto, Massimo Pregnolato, Marina Lotti, Marco Terreni “Recombinant lipase from Candida rugosa for regioselective hydrolysis of peracetylated nucleosides. A comparison with commercial non recombinant lipases”. Biocatalysis and Biotrasformation, 28, (9) 108-116; (2010)

Caterina Temporini, Paolo Bonomi, Immacolata Serra, Auro Tagliani, Teodora Bavaro, Daniela Ubiali, Gabriella Massolini, Marco Terreni“Characterization and study of the orientation of immobilized enzyme by tryptic digestion and HPLC-MS: design of an efficient catalyst for the synthesis of cephalosporins” Biomacromolecules, 11, 1623-1632 (2010)

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