Elena Raimondi
Elena Raimondi
e-mail:
affiliation: Università di Pavia
research area(s): Genetics And Genomics, Cell Biology
Course: Genetics, Molecular and Cellular Biology
University/Istitution: Università di Pavia
ACADEMIC POSITION
Associate Professor of Genetics, Department of Genetics and Microbiology “A. Buzzati-Traverso”, Faculty of Sciences, University of Pavia, Via Ferrata 1, 27100 Pavia, Italy.
PLACE AND DOB: Milan, May 13, 1959
EDUCATION
1987: Ph.D. degree in Genetic Sciences (Genetics and Molecular Biology), University of Pavia, Italy.
1982: Degree (Laurea) cum laude in Biological Sciences, University of Milan, Italy
PROFESSIONAL EXPERIENCE
2001-present – Associate Professor of Genetics, charged of the Cytogenetics, Human Cytogenetics and Molecular Cytogenetics modules in five courses for the Biological Sciences University Degree and for the Applied Biology Specialistic degree, Faculty of Sciences, University of Pavia.
1993 - University of Pavia, Faculty of Sciences, charged of the Cytogenetics and Genetics (Cytogenetics) courses for the Biological Sciences Degree.
1992 - University of Pavia, Faculty of Sciences, charged of the Environmental Mutagenesis course for the Biological Sciences Degree.
1991 – Associate Professor of Genetics.
1991 – Visiting fellow, in the Prof. U. Claussen Laboratory, Erlangen, Nurnberg University.
1990-2005 – Coordinator of the courses of Cytogenetics I, Cytogenetics II and Mutagenesis for the Specialization School of Applied Genetics, Faculty of Sciences, University of Pavia, Italy.
1990 - Fellow of the "Fondazione Anna Villa Rusconi" at the Department of Genetics and Microbiology, University of Pavia, Italy.
1988-1989, 1989-1990 e 1990-1991 – “Professore a Contratto” Faculty of Sciences, University of Pavia, Italy.
1988 – Fellow of the Italian National Research Council, at the Faculty of Sciences, University of Pavia, Italy.
1987 - Visiting fellow, in the Prof. B.D. Young Laboratory, ICRF London.
1987 - Visiting fellow, in the Prof. M. Sthoer Laboratory, DKFZ Heidelberg University.
1986-2001 – Coordinator of the course “Structure and function of the eukaryoitic chromosome”, Ph.D. Program in Genetic Sciences (Genetics and Molecular Biology), University of Pavia, Italy.
1985 - Visiting fellow, in the Prof. J.F. Mattei Laboratory, INSERM Marseille.
1983-1987 – Doctoral fellow at the Department of Genetics and Microbiology University of Pavia, in the Prof. L. De Carli Laboratory.
1982-1983 – Fellow at the “Centro Studi di Genetica Umana” University of Milan, directed by Prof. G. Morganti.
ADDITIONAL INFORMATION
Member of the Italian Federation of Life Sciences (FISV).
Member of the Italian Society of Human Genetics (SIGU).
Member of the European Cytogenetics Society (ECS).
From 1997 to 1998 she has been a member of the directive committee of the Italian Association of Genetics (AGI).
She reviewed grant applications presented to the Italian Ministero dell’Università e della Ricerca Scientifica.
She was granted AIRC contracts, Telethon contracts (1995-1997), as well as national projects funded by MIUR (PRIN 2000-present) where he acted as local coordinator.
She is author of 68 papers on peer-reviewed journals and international books, of a number of meeting communications, of book chapters and she has participated, as invited speaker, to numerous National and International Congresses.
1) Chromosome pathology and cancer cytogenetics; 2) high resolution cytogenetic analysis and molecular cytogenetics; 3) centromere molecular organization and function; 3) chromosome engineering, construction of mammalian artificial chromosomes; 4) mammalian genome plasticity and evolution.
Current scientific interests
Analysis of DNA sequences that drive human genome plasticity – a) Identification, molecular characterization and sequence analysis, of segmental duplications mediating de novo chromosome rearrangements. b) Identification, molecular characterization and sequence analysis, of genome segments mapping in hot-spots of hereditary diseases and cancer associated rearrangement. c) Physical mapping, by means of molecular cytogenetic approaches, of large deletions involving the APC (Adenomatous Polyposis Coli) locus in FAP (Familial Adenomatous Polyposis) patients.
Analysis of DNA sequences driving mammalian karyotype evolution – a) Identification of low copy repeated sequences (LCRs) that make, specific mammalian genome regions, structural rearrangement prone. b) Investigation of the mechanism by which LCRs can promote mammalian genomes remodelling.
Analysis of the evolution of Equid Karyotype (work performed with E. Giulotto, University of Pavia) – a) Study of the molecular organization and chromosomal distribution of satellite DNA sequences in different species of the genus Equus. b) Analysis of coupling between repeated DNA families and centromere function in different species of the genus Equus.
Identification of new satellite-DNA families in equid species (work performed with E. Giulotto, University of Pavia).
1. Balestrazzi A., Agoni V., Tava A., Avato P., Biazzi E., Raimondi E., Macovei A., Carbonera D. (2011). Cell death induction and nitric oxide biosynthesis in white poplar (Populus alba L.) suspension cultures exposed to alfalfa saponins. Physiologia Plantarum 141: 227-238.
2. Balestrazzi A., Macovei A., Tava A., Avato P., Raimondi E., Carbonera D. (2011). Unraveling the response of plant cells to cytotoxic saponins: role of metallothionein and nitric oxide. Plant Signaling & Behavior 6: 1-4.
3. Raimondi E., Piras F.M., Nergadze S.G., Di Meo G.P., Ruiz-Herrera A., Ponsà M., Ianuzzi L., Giulotto E. (2011). Polymorphic organization of constitutive heterochromatin in Equus asinus (2n=62) chromosome 1. Hereditas 148: 110-113.
4. Raimondi E. (2011). Naturally occurring minichromosome platforms in chromosome engineering: an overview. Methods in Molecular Biology 738: 41-56.
5. Piras F.M., Nergadze S.G., Magnani E., Bertoni L., Attolini C., Khoriauli L., Raimondi E., Giulotto E. (2010). Uncoupling of satellite DNA and centromeric function in the genus Equus. PLoS Genetics 6: e1000845.
6. Balestrazzi A., Macovei A., Testoni C., Raimondi E., Donà M., Carbonera D. (2009). Nitric oxide biosynthesis in white poplar (Populus alba L.) suspension cultures challenged with heavy metals. Plant Stress 3: 1-6.
7. Piras F.M., Nergadze S.G., Poletto V., Cerutti F., Ryder O.A., Leeb T., Raimondi E., Giulotto E. (2009). Phylogeny of horse chromosome 5q in the genus Equus and centromere repositioning. Cytogenetic And Genome Research 126: 165-172.
8. Paulis M., Bensi M., Orioli D., Mondello C., Mazzini G., Dincalci M., Falcioni C., Radaelli E., Erba E., Raimondi E., De Carli L. (2007). Transfer of a human chromosomal vector from a hamster cell line to a mouse embryonic stem cell line. Stem Cells 25: 2254-2550.
9. Uboldi C., Paulis M., Guidi E., Bertoni A., Di Meo G.P., Perucatti A., Iannuzzi L., Raimondi E., Brunner R.M., Eggen A., Ferretti L. (2006). Cloning of the bovine prion-like Shadoo(SPRN) gene by comparative analysis of the predicted genomic locus. Mammalian Genome 17: 1130-1139.
10. Paulis M., Bensi M., Moralli D., De Carli L., Raimondi E. (2006). A set of duplicons on human chromosome 9 is involved in the origin of a supernumerary marker chromosome. Genomics 87: 747-757.
11. Torti C., Gomulski L., Bonizzoni M., Murelli V., Moralli D., Guglielmino C.; Raimondi E., Crisafulli D., Capy P., Gasperi G., Malacrida A. (2005). Cchobo, a hobo-related sequence in Ceratitis capitata. Genetica 123: 313-325.
12. Uboldi C., Del Vecchio I., Foti M.G., Azzalin A., Paulis M., Raimondi E., Vaccari G., Agrimi U., Di Guardo G., Comincini S., Ferretti L. (2005). Prion-like Doppel gene (PRND) in the goat: genomic structure, cDNA and polymorphisms. Mammalian Genome 16: 963-971.
13. Paulis M., Moralli D., Bensi M., De Carli L., Raimondi E. (2004). Isolation from the horse genome of a new DNA transposon belonging to the Tigger family. Mammalian Genome 15: 399-403.
14. Nano R., Invernizzi R., Facoetti A., Raimondi E., Moralli D., Gerzeli G. (2003). Quantification of the DHFR gene in blast cells of leukaemia patients by fluorescence in situ hybridisation. Anticancer Research 23: 3883-3388.
15. Paulis M., Moralli D., Bensi M., De Carli L., Raimondi E. (2003). Identification of human pericentromeric DNA sequences promoting chromosome rearrangements. Annales De Genetique 46: 340.
16. Invernizzi R., Nano R., Facoetti A., Raimondi E., Travaglino E., Moralli D. (2002). Analysis of the dihydrofolate reductase gene in blast cells of patients with acute leukemia by fluorescence in situ hybridization. Haematologica 87: 61-62.
17. Denegri M., Moralli D., Rocchi M., Biggiogera M., Raimondi E., Cobianchi F., De Carli L., Riva S., Biamonti G. (2002). Human chromosomes 9, 12, and 15 contain the nucleation sites of stress-induced nuclear bodies. Molecular Biology of The Cell 13: 2069-2079.
No projects are available to students for the current accademic year.