Giovanna Riccardi
e-mail: giovanna.riccardi AT unipv.it
affiliation: Università di Pavia
research area(s): Molecular Biology, Genetics And Genomics
Course:
Biomolecular Sciences and Biotechnology
University/Istitution: Istituto Universitario di Studi Superiori, Pavia
University/Istitution: Istituto Universitario di Studi Superiori, Pavia
ACADEMIC POSITION
Full Professor of Microbiology, University of Pavia
EDUCATION
1972- High School Diploma, Scientific Liceum “T. Taramelli” – Pavia.
1976 - Doctoral Degree cum laude in Biology (University of Pavia).
Full Professor of Microbiology, University of Pavia
EDUCATION
1972- High School Diploma, Scientific Liceum “T. Taramelli” – Pavia.
1976 - Doctoral Degree cum laude in Biology (University of Pavia).
The research field regards mechanisms of antibiotic resistance in mycobacteria and in Burkholderia cenocepacia, a cystic fibrosis pathogen. Her laboratory has identified the target of a new antitubercular drug, belonging to the class of benzothiazinones, as well as the mechanism of resistance to this drug. Both discoveries have been patented and one of these patents has been licensed to Sentinel Diagnostics. On cystic fibrosis pathogens, her group is involved in the study of drug resistance due to efflux pumps, having established several collaborations with Italian and foreign partners.
Bazzini S, Udine C, Sass A, Pasca MR, Longo F, Emiliani G, Fondi M, Perrin E, Decorosi F, Viti C, Giovannetti L, Leoni L, Fani R, Riccardi G, Mahenthiralingam E, Buroni S. (2011) Deciphering the Role of RND Efflux Transporters in Burkholderia cenocepacia. PLoS One. 6:e18902.
Lucarelli AP, Buroni S, Pasca MR, Rizzi M, Cavagnino A, Valentini G, Riccardi G, Chiarelli LR. (2010) Mycobacterium tuberculosis Phosphoribosyl Pyrophosphate Synthetase: Biochemical Features of a Crucial Enzyme for Mycobacterial Cell Wall Biosynthesis. PLoS ONE. 5:e15494.
Manina G, Bellinzoni M, Pasca MR, Neres J, Milano A, de Jesus Lopes Ribeiro AL, Buroni S, Skovierová H, Dianišková P, Mikušová K, Marák J, Makarov V, Giganti D, Haouz A, Lucarelli AP, Degiacomi G, Piazza A, Chiarelli LR, De Rossi E, Salina E, Cole ST, Alzari PM, Riccardi G. (2010) Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance. Mol Microbiol. 77:1172-85.
Manina G, Pasca MR, Buroni S, De Rossi E, Riccardi G. (2010) Decaprenylphosphoryl-β-D-ribose 2’-epimerase from Mycobacterium tuberculosis is a magic target. Current Medicinal Chemistry. 17:3099-108.
Pasca MR, Degiacomi G, de Jesus Lopes Ribeiro AL, Zara F, De Mori P, Mirrione M, Brerra R, Pagani L, Pucillo L, Troupioti P, Makarov V, Cole ST, Riccardi G. (2010) Clinical Isolates of Mycobacterium tuberculosis in Four European Hospitals are Uniformly Susceptible to Benzothiazinones Antimicrob Agents Chemother. 54:1616-8.
Boldrin F, Casonato S, Dainese E, Sala C, Dhar N, Palù G, Riccardi G, Cole S, Manganelli R. (2010) Development of a repressible mycobacterial promoter system based on two transcriptional repressors. Nucleic Acids Res. 1–11 doi:10.1093/nar/gkq235.
Christophe T, Jackson M, Kyoung Jeon H, Fenistein D, ContrerasDominguez M, Kim J, Genovesio A, Carralot JP, Ewann F, Hye Kim E, Yeon Lee S, Kang S, Jung Seo M, Jung Park E, Skovierova H, Pham H, Riccardi G, Nam J, Marsollier L, Kempf M, Joly-Guillon ML, Oh T, Kyung Shin W, No Z, Nehrbass U, Brosch R, Cole ST, Brodin P. (2009) High content screening identifies decaprenyl-phosphoribose 2’ epimerase as a target for intracellular inhibitors. Plos Pathogens. 5:e1000645.
Makarov V, Manina G, Mikusova K, Möllmann U, Ryabova O, Saint-Joanis B, Dhar N, Pasca MR, Buroni S, Lucarelli AP, Milano A, De Rossi E, Belanova M, Bobovska A, Dianiskova P, Kordulakova J, Sala C, Fullam E, Schneider P, McKinney JD, Brodin P, Christophe T, Waddell S, Butcher P, Albrethsen J, Rosenkrands I, Brosch R, Nandi V, Bharath S, Gaonkar S, Shandil RK, Balasubramanian V, Balganesh T, Tyagi S, Grosset J, Riccardi G, Cole ST. (2009) Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis. Science. 2009. 324:801-4.
Lucarelli AP, Buroni S, Pasca MR, Rizzi M, Cavagnino A, Valentini G, Riccardi G, Chiarelli LR. (2010) Mycobacterium tuberculosis Phosphoribosyl Pyrophosphate Synthetase: Biochemical Features of a Crucial Enzyme for Mycobacterial Cell Wall Biosynthesis. PLoS ONE. 5:e15494.
Manina G, Bellinzoni M, Pasca MR, Neres J, Milano A, de Jesus Lopes Ribeiro AL, Buroni S, Skovierová H, Dianišková P, Mikušová K, Marák J, Makarov V, Giganti D, Haouz A, Lucarelli AP, Degiacomi G, Piazza A, Chiarelli LR, De Rossi E, Salina E, Cole ST, Alzari PM, Riccardi G. (2010) Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance. Mol Microbiol. 77:1172-85.
Manina G, Pasca MR, Buroni S, De Rossi E, Riccardi G. (2010) Decaprenylphosphoryl-β-D-ribose 2’-epimerase from Mycobacterium tuberculosis is a magic target. Current Medicinal Chemistry. 17:3099-108.
Pasca MR, Degiacomi G, de Jesus Lopes Ribeiro AL, Zara F, De Mori P, Mirrione M, Brerra R, Pagani L, Pucillo L, Troupioti P, Makarov V, Cole ST, Riccardi G. (2010) Clinical Isolates of Mycobacterium tuberculosis in Four European Hospitals are Uniformly Susceptible to Benzothiazinones Antimicrob Agents Chemother. 54:1616-8.
Boldrin F, Casonato S, Dainese E, Sala C, Dhar N, Palù G, Riccardi G, Cole S, Manganelli R. (2010) Development of a repressible mycobacterial promoter system based on two transcriptional repressors. Nucleic Acids Res. 1–11 doi:10.1093/nar/gkq235.
Christophe T, Jackson M, Kyoung Jeon H, Fenistein D, ContrerasDominguez M, Kim J, Genovesio A, Carralot JP, Ewann F, Hye Kim E, Yeon Lee S, Kang S, Jung Seo M, Jung Park E, Skovierova H, Pham H, Riccardi G, Nam J, Marsollier L, Kempf M, Joly-Guillon ML, Oh T, Kyung Shin W, No Z, Nehrbass U, Brosch R, Cole ST, Brodin P. (2009) High content screening identifies decaprenyl-phosphoribose 2’ epimerase as a target for intracellular inhibitors. Plos Pathogens. 5:e1000645.
Makarov V, Manina G, Mikusova K, Möllmann U, Ryabova O, Saint-Joanis B, Dhar N, Pasca MR, Buroni S, Lucarelli AP, Milano A, De Rossi E, Belanova M, Bobovska A, Dianiskova P, Kordulakova J, Sala C, Fullam E, Schneider P, McKinney JD, Brodin P, Christophe T, Waddell S, Butcher P, Albrethsen J, Rosenkrands I, Brosch R, Nandi V, Bharath S, Gaonkar S, Shandil RK, Balasubramanian V, Balganesh T, Tyagi S, Grosset J, Riccardi G, Cole ST. (2009) Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis. Science. 2009. 324:801-4.
No projects are available to students for the current accademic year.