Born in Naples on March 5, 1948
POSITION TITLE:
Full Professor of Neurology and Chairman of the Department of Neurological Sciences at Federico II, Naples, Italy.
EDUCATION :
1972 Medical Degree at the University of Naples
1973 Educational Council for Foreign Medical Graduates Certification
1975 Board Certification in Neurology
CLINICAL TRAINING/RESEARCH EXPERIENCE:
1976-78 Fellow of Research at the Department of Neurobiology of the Institute of Clinical Research of Montreal (Dr. A. Barbeau)
1992 Stage at the National Hospital, Queen Square, London (Dr. A. Harding)
1994 Stage at Columbia University, New York (Dr. S. Fahn)
1996 Stage at Hopital de la Salpetriere (Dr. Y. Agid)
ACADEMIC AND PROFESSIONAL DUTIES
1973 Assistant Professor of Anatomy
1974 Lecturer of Neurology at the Federico II University, Naples
1982 Senior Lecturer of Neurology
1982 Visiting Professor of Pharmacology and Neuropediatrics at University of Arizona
1992 Associate Professor of Neurology
2001 Full Professor of Neurology
2003 Chairman of the Department of Neurological Sciences

RESEARCH FIELDS
Molecular genetics and molecular pathogenesis of the recessive and dominant ataxias;
Molecular genetics and molecular pathogenesis of the hereditary spastic paraplegias;
Molecular genetics and molecular pathogenesis in Parkinson disease and parkinsonisms;
Epidemiology of hereditary ataxias and spastic paraplegias;
Clinical studies in hereditary ataxias;
Trials in hereditary ataxias;
Multiple sclerosis and markers.

Saccà F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Perrotta G, Carotenuto B, Marsili A, Palma V, De Michele G, Brunetti A, Brescia Morra V, Filla A, Salvatore M. (2011) A randomized controlled clinical trial of growth hormone in amyotrophic lateral sclerosis: clinical, neuroimaging, and hormonal results. J Neurol. 2011 Jun 25.
Criscuolo C, De Rosa A, Guacci A, Simons EJ, Breedveld GJ, Peluso S, Volpe G, Filla A, Oostra BA, Bonifati V, De Michele G. (2011) The LRRK2 R1441C mutation is more frequent than G2019S in Parkinson's disease patients from Southern Italy. Mov Disord. 2011 Apr 29.
Saccà F, Piro R, De Michele G, Acquaviva F, Antenora A, Carlomagno G, Cocozza S, Denaro A, Guacci A, Marsili A, Perrotta G, Puorro G, Cittadini A, Filla A. (2011) Epoetin alfa increases frataxin production in Friedreich's ataxia without affecting hematocrit. Mov Disord. 26:739-42.
Pellecchia MT, Barone P, Vicidomini C, Mollica C, Salvatore E, Ianniciello M, Liuzzi R, Longo K, Picillo M, De Michele G, Filla A, Brunetti A, Salvatore M, Pappatà S. (2011) Progression of striatal and extrastriatal degeneration in multiple system atrophy: A longitudinal diffusion-weighted MR study.
Mov Disord. 26:1303-9.
Saccà F, Puorro G, Antenora A, Marsili A, Denaro A, Piro R, Sorrentino P, Pane C, Tessa A, Brescia Morra V, Cocozza S, De Michele G, Santorelli FM, Filla A. (2011) A combined nucleic acid and protein analysis in Friedreich ataxia: implications for diagnosis, pathogenesis and clinical trial design. PLoS One 6:e17627
SACC" F., PIRO R., DE MICHELE G., ACQUAVIVA F., ANTENORA A., CARLOMAGNO G., COCOZZA S., DENARO A., GUACCI A., MARSILI A., PERROTTA G., PUORRO G., CITTADINI A., FILLA A. (2011). Epoetin alfa increases frataxin production in Friedreich's ataxia without affecting hematocrit. . MOVEMENT DISORDERS. pp. 4:739-742
SALVATORE E, DI MAIO L, FILLA A, FERRARA AM, RINALDI C, SACC" F, PELUSO S, MACCHIA PE, PAPPAT" S, DE MICHELE G (2010). Benign hereditary chorea: clinical and neuroimaging features in an Italian family.. MOVEMENT DISORDERS. pp. 6:1491-1496
DE LEVA MF., FILLA A., CRISCUOLO C., TESSA A., PAPPAT" S., QUARANTELLI M., BILO L., PELUSO S., ANTENORA A., LONGO D., SANTORELLI FM., DE MICHELE G. (2009). Complex phenotype in an Italian family with a novel mutation in SPG3A.. JOURNAL OF NEUROLOGY.
RINALDI C, RUSSO CV, FILLA A, DE MICHELE G, MARANO E. (2009). Course and outcome of a voltage-gated potassium channel antibody negative Morvan's syndrome.. NEUROLOGICAL SCIENCES. pp. 3:237-239
CRISCUOLO C, FILLA A, COPPOLA G, RINALDI C, CARBONE R, PINTO S, WANG Q, DE LEVA MF, SALVATORE E, BANFI S, BRUNETTI A, QUARANTELLI M, GESCHWIND DH, PAPPAT" S, DE MICHELE G. (2009). Two novel CYP7B1 mutations in Italian families with SPG5: a clinical and genetic study.. JOURNAL OF NEUROLOGY. pp. 6:1252-1257
RINALDI C, TUCCI T, MAIONE S, GIUNTA A, DE MICHELE G, FILLA A. (2009). Low-dose idebenone treatment in Friedreich's ataxia with and without cardiac hypertrophy.. JOURNAL OF NEUROLOGY. pp. 4:1434-1437 DENORA PS, SCHLESINGER D, CASALI C, KOK F, TESSA A, BOUKHRIS A, AZZEDINE H, DOTTI MT, BRUNO C, TRUCHETTO J, BIANCHERI R, FEDIRKO E, DI ROCCO M, BUENO C, MALANDRINI A, BATTINI R, SICKL E, DE LEVA MF, BOESPFLUG-TANGUY O, SILVESTRI G, SIMONATI A, SAID E, FERBERT A, CRISCUOLO C, HEINIMANN K, MODONI A, WEBER P, PALMERI S, PLASILOVA M, PAURI F, CASSANDRINI D, BATTISTI C, PINI A, TOSETTI M, HAUSER E, MASCIULLO M, DI FABIO R, PICCOLO F, DENIS E, CIONI G, MASSA R, DELLA GIUSTINA E, CALABRESE O, MELONE MA, DE MICHELE G, FEDERICO A, BERTINI E, DURR A, BROCKMANN K, VAN DER KNAAP MS, ZATZ M, FILLA A, BRICE A, STEVANIN G, SANTORELLI FM. (2009). Screening of ARHSP-TCC patients expands the spectrum of SPG11 mutations and includes a large scale gene deletion. . HUMAN MUTATION. pp.:500-519
VARRONE A, SANSONE V, PELLECCHIA MT, AMBONI M, SALVATORE E, DE MICHELE G, FILLA A, BARONE P, PAPPAT" S, SALVATORE M. (2008). Comparison between a dual-head and a brain-dedicated SPECT system in the measurement of the loss of dopamine transporters with [123I]FP-CIT. . EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. pp. 7:1343-1349
PELLECCHIA MT, BARONE P, MOLLICA C, SALVATORE E, IANNICIELLO M, LONGO K, VARRONE A, VICIDOMINI C, PICILLO M, DE MICHELE G, FILLA A, SALVATORE M, PAPPAT" S. (2008). Diffusion-weighted imaging in multiple system atrophy: A comparison between clinical subtypes.. MOVEMENT DISORDERS. pp. 8:689-696

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