Giuseppe Salemi
e-mail: gsalemi AT unipa.it
affiliation: Università di Palermo
research area(s): Neuroscience, Experimental Medicine
Course:
Cell Biology
University/Istitution: Università di Palermo
University/Istitution: Università di Palermo
1977-1979 Internal student, Institute of Biochemistry, University of Palermo. Dr. Filippo Cacioppo, Professor and Chairman. Topic of research: retinol-binding proteins in mouse retina.
1980-1981 Internal student, Institute of General Pathology, University of Palermo. Dr. Alfredo Salerno, Professor and Chairman. Topic of research: Lymphocyte subpopulations in LLA and LLC.
August 1981 Fellowship, Lehrstuhl fur medizinische Mikrobiologie und Immunologia, Ruhr Universitat,Bochum, FRG. Dr. W. Konig, Professor and Chairman.
1981-1983 Internal student, Cellular and Developmental Biology, University of Palermo, Dr. Giovanni Giudice, Professor and Chairman. Laboratory of Neurobiology, directed by Dr. Alessandro Cestelli. Topic of research: nucleosomal repeat length of oligodendrocyte during development.
1983 Internal student, Institute of Neuropsichiatry, University of Palermo. Dr. Andrea Scoppa, Professor and Chairman.
November 1983 Degree cum laude in Medicine and Surgery; graduation thesis: "Studi biochimici sulla cromatina dell'oligodendrocita al momento della sintesi della proteina basica della mielina (MBP)".
1983-1987 Post doctoral fellow. Institute of Neuropsichiatry, University of Palermo, Dr. Andrea Scoppa, Professor and Chairman. Topics of research: 1) Influence of thyroid hormones on neuronal differentiation in a serum-free culture system; 2) Influence of serum from Multiple Sclerosis (MS) patients on CNS rat cells in culture; 3) Incidence, prevalence and mortality of Amyothropic Lateral Sclerosis (ALS) in Palermo Province.
1987 Board in Neurology cum laude, graduation thesis: "La storia naturale della Sclerosi Laterale Amiotrofica attraverso un'indagine epidemiologica descrittiva nella provincia di Palermo negli anni 1973-1984".
1987-1989 Fellowship. Institute of Neuropsichiatry, University of Palermo. Dr. Federico Piccoli, Professor and Chairman. Laboratory of Neuroepidemiology, directed by Dr. Giovanni Savettieri, Professor. Topic of research: Descriptive epidemiology of several neurological disorders in Sicily (multicentre, door-to-door survey).
1990-1996 Assistant professor, Institute of Neuropsichiatry, University of Palermo. Dr. Federico Piccoli, Professor and Chairman. Laboratory of Neuroepidemiology: Descriptive epidemiology of several neurological disorders in Sicily (multicentre, door-to-door survey). Descriptive epidemiology of MS in Sicily. Laboratory of Neurobiology, directed by Dr Giovanni Savettieri, Professor. Topics of research: 1) Expression of Synapsin I in neuronal cell cultures and influence of triiodothyronine; 2) Composition of nuclear matrix in neuronal and glial cell nuclei during development. Outpatient service for patients affected by MS.
1996-1997 Fellowship. Institute of Human Molecular Genetics, Istituto Gaslini, Genoa Dr. Giovanni Romeo, Professor and Chairman. Topic of research: Molecular genetic of Currarino syndrome, spine bifida, and ano-rectal malformations.
1997-2001 Assistant professor, Institute of Neuropsichiatry, University of Palermo. Dr. Giovanni Savettieri, Professor and Chairman. Topics of research: Neuroepidemiology: Survival of Parkinson disease (PD). Analytical epidemiology of MS, PD, and Essential Tremor (ET). Accuracy of death certificates for MS and ALS. Neurogenetics: Molecular genetic analysis of MS and ET families. Outpatient service for patients affected by MS.
01 January 2001 Associate professor, Institute of Neuropsichiatry, University of Palermo. Dr. Giovanni Savettieri, Professor and Chairman.
January 2006 Chief of Unit of diagnosis and therapy of Demyelinating Disorders and Multiple Sclerosis, University of Palermo
1980-1981 Internal student, Institute of General Pathology, University of Palermo. Dr. Alfredo Salerno, Professor and Chairman. Topic of research: Lymphocyte subpopulations in LLA and LLC.
August 1981 Fellowship, Lehrstuhl fur medizinische Mikrobiologie und Immunologia, Ruhr Universitat,Bochum, FRG. Dr. W. Konig, Professor and Chairman.
1981-1983 Internal student, Cellular and Developmental Biology, University of Palermo, Dr. Giovanni Giudice, Professor and Chairman. Laboratory of Neurobiology, directed by Dr. Alessandro Cestelli. Topic of research: nucleosomal repeat length of oligodendrocyte during development.
1983 Internal student, Institute of Neuropsichiatry, University of Palermo. Dr. Andrea Scoppa, Professor and Chairman.
November 1983 Degree cum laude in Medicine and Surgery; graduation thesis: "Studi biochimici sulla cromatina dell'oligodendrocita al momento della sintesi della proteina basica della mielina (MBP)".
1983-1987 Post doctoral fellow. Institute of Neuropsichiatry, University of Palermo, Dr. Andrea Scoppa, Professor and Chairman. Topics of research: 1) Influence of thyroid hormones on neuronal differentiation in a serum-free culture system; 2) Influence of serum from Multiple Sclerosis (MS) patients on CNS rat cells in culture; 3) Incidence, prevalence and mortality of Amyothropic Lateral Sclerosis (ALS) in Palermo Province.
1987 Board in Neurology cum laude, graduation thesis: "La storia naturale della Sclerosi Laterale Amiotrofica attraverso un'indagine epidemiologica descrittiva nella provincia di Palermo negli anni 1973-1984".
1987-1989 Fellowship. Institute of Neuropsichiatry, University of Palermo. Dr. Federico Piccoli, Professor and Chairman. Laboratory of Neuroepidemiology, directed by Dr. Giovanni Savettieri, Professor. Topic of research: Descriptive epidemiology of several neurological disorders in Sicily (multicentre, door-to-door survey).
1990-1996 Assistant professor, Institute of Neuropsichiatry, University of Palermo. Dr. Federico Piccoli, Professor and Chairman. Laboratory of Neuroepidemiology: Descriptive epidemiology of several neurological disorders in Sicily (multicentre, door-to-door survey). Descriptive epidemiology of MS in Sicily. Laboratory of Neurobiology, directed by Dr Giovanni Savettieri, Professor. Topics of research: 1) Expression of Synapsin I in neuronal cell cultures and influence of triiodothyronine; 2) Composition of nuclear matrix in neuronal and glial cell nuclei during development. Outpatient service for patients affected by MS.
1996-1997 Fellowship. Institute of Human Molecular Genetics, Istituto Gaslini, Genoa Dr. Giovanni Romeo, Professor and Chairman. Topic of research: Molecular genetic of Currarino syndrome, spine bifida, and ano-rectal malformations.
1997-2001 Assistant professor, Institute of Neuropsichiatry, University of Palermo. Dr. Giovanni Savettieri, Professor and Chairman. Topics of research: Neuroepidemiology: Survival of Parkinson disease (PD). Analytical epidemiology of MS, PD, and Essential Tremor (ET). Accuracy of death certificates for MS and ALS. Neurogenetics: Molecular genetic analysis of MS and ET families. Outpatient service for patients affected by MS.
01 January 2001 Associate professor, Institute of Neuropsichiatry, University of Palermo. Dr. Giovanni Savettieri, Professor and Chairman.
January 2006 Chief of Unit of diagnosis and therapy of Demyelinating Disorders and Multiple Sclerosis, University of Palermo
1) Characterization of proteomic patterns of cerebrospinal fluid and sera in patients affected by Multiple Sclerosis. 2) Characterization of purine, vitamins, lipids and stress factors in sera from patients affected by Multiple Sclerosis. 3) Carrier status of JC virus and risk of Progressive Multifocal Leukoencephalopathy in patients affected by Multiple Sclerosis and treated with different immunotherapies.
1 " Savettieri G, De Marco EV, Civitelli D, Salemi G, Nicoletti G, Annesi G, Cirò Candiano IC, Quattrone A: (2001) Lack of association between ubiquitin carboxy-terminal hydrolase L1 gene polymorphism and PD.Neurology 57: 560-561.
2 " D"Alfonso S, Mellai M, Giordano M, Pastore A, Malferrari G, Naldi P, Repice A, Liguori M, Cannoni S, Milanese C, Caputo D, Savettieri G, Momigliano-Richiardi P, (2002) The Italian Group for the Study of Multiple Sclerosis genetics (also includes: Leone M, Ferro I, Massacesi L, Ballerini C, Trojano M, Bomprezzi R, Ristori G, La Mantia L, Vacca D, Losciale L, Guerini FR, Salemi G, Cuccia G). Identification of single nucleotide variations in the coding and regulatory regions of the myelin-associated glycoprotein gene and study of their association with multiple sclerosis. J Neuroimmunol. 126(1-2):196-204.
3. Savettieri G, Andreoli V, Bonavita S, Cittadella R, Caltagirone C, Fazio MC, Girlanda P, Le Pira F, Liguori M, Logroscino G, Lugaresi A, Nocentini U, Reggio A, Salemi G, Serra P, Tedeschi G, Toma L, Trojano M, Valentino P, Quattrone A. (2003): Apolipoprotein E genotype does not influence the progression of multiple sclerosis. J Neurol. 250: 1094-1098.
4. Liguori M, Sawcer S, Setakis E, Compston A, Giordano M, D'Alfonso S, Mellai M, Malferrari G, Trojano M, Livrea P, De Robertis F, Massacesi L, Repice A, Ballerini C, Biagioli T, Bomprezzi R, Cannoni S, Ristori G, Salvetti M, Grimaldi LM, Biunno I, Comi G, Leone M, Ferro I, Naldi P, Milanese C, Gellera C, Loredana LM, Savettieri G, Salemi G, Aridon P, Caputo D, Rosa Guerini F, Ferrante P, Momigliano-Richiardi P. (2003) A whole genome screen for linkage disequilibrium in multiple sclerosis performed in a continental Italian population. J Neuroimmunol. 143: 97-100.
5. Brassat D, Salemi G, Barcellos L.F, McNeill G, Proia P, Hauser S.L, Oksenberg J.R., Savettieri G. (2005) The HLA locus and multiple sclerosis in Sicily. Neurology 64:361-363.
6. Forte GI, Ragonese P, Salemi G., Scola L, Candore G, D'Amelio M, Crivello A, Di Benedetto N, Nuzzo D, Giacalone A, Lio D, Caruso C. (2006) Search for genetic factors associated with susceptibility to Multiple Sclerosis. Ann.New York Acad Sci 1067:264-269.
7 - Aridon P, Ragonese P, De Fusco M, Lo Coco D, Salemi G., Casari G, Savettieri G. (2007) Autosomal dominant hereditary spastic paraplegia: report of a large italian family with R581X spastin mutation. Neurol Sci. 28:171-174.
8 - Aridon P, Ragonese P, De Fusco M, Salemi G., Casari G, Savettieri G. (2008) Further evidence of genetic heterogeneity in familial essential tremor. Parkinsonism & Related Disorders. 14:15-18.
9 - Savettieri G, Annesi G, Civitelli D, Cirò Candiano IC, Salemi G, Ragonese P, Annesi F, Tarantino P, Terruso V, D'Amelio M, Quattrone A (2008) Identification of the novel D297fsX318 PINK1 mutation and phenotype variation in a family with early-onset Parkinson's disease. Parkinsonism Relat Disord.14:509-512.
10 - Salemi G, Gueli MC, D'Amelio M, Saia V, Mangiapane P, Aridon P, Ragonese P, Lupo I. (2009) Blood levels of homocysteine, cysteine, glutathione, folic acid, and vitamin B(12) in the acute phase of atherothrombotic stroke. Neurol Sci. 30:361-364.
11 - Proia P, Schiera G, Salemi G, Ragonese P, Savettieri G, Di Liegro I. (2009) Neuronal and BBB damage induced by sera from patients with secondary progressive multiple sclerosis. Int J Mol Med. 24:743-747.
12 - Salemi G, Gueli MC, Vitale F, Battaglieri F, Guglielmini E, Ragonese P, Trentacosti A, Massenti MF, Savettieri G, Bono A. (2010) Blood lipids, homocysteine, stress factors, and vitamins in clinically stable multiple sclerosis patients. Lipids Health Dis. 18;9:19.
2 " D"Alfonso S, Mellai M, Giordano M, Pastore A, Malferrari G, Naldi P, Repice A, Liguori M, Cannoni S, Milanese C, Caputo D, Savettieri G, Momigliano-Richiardi P, (2002) The Italian Group for the Study of Multiple Sclerosis genetics (also includes: Leone M, Ferro I, Massacesi L, Ballerini C, Trojano M, Bomprezzi R, Ristori G, La Mantia L, Vacca D, Losciale L, Guerini FR, Salemi G, Cuccia G). Identification of single nucleotide variations in the coding and regulatory regions of the myelin-associated glycoprotein gene and study of their association with multiple sclerosis. J Neuroimmunol. 126(1-2):196-204.
3. Savettieri G, Andreoli V, Bonavita S, Cittadella R, Caltagirone C, Fazio MC, Girlanda P, Le Pira F, Liguori M, Logroscino G, Lugaresi A, Nocentini U, Reggio A, Salemi G, Serra P, Tedeschi G, Toma L, Trojano M, Valentino P, Quattrone A. (2003): Apolipoprotein E genotype does not influence the progression of multiple sclerosis. J Neurol. 250: 1094-1098.
4. Liguori M, Sawcer S, Setakis E, Compston A, Giordano M, D'Alfonso S, Mellai M, Malferrari G, Trojano M, Livrea P, De Robertis F, Massacesi L, Repice A, Ballerini C, Biagioli T, Bomprezzi R, Cannoni S, Ristori G, Salvetti M, Grimaldi LM, Biunno I, Comi G, Leone M, Ferro I, Naldi P, Milanese C, Gellera C, Loredana LM, Savettieri G, Salemi G, Aridon P, Caputo D, Rosa Guerini F, Ferrante P, Momigliano-Richiardi P. (2003) A whole genome screen for linkage disequilibrium in multiple sclerosis performed in a continental Italian population. J Neuroimmunol. 143: 97-100.
5. Brassat D, Salemi G, Barcellos L.F, McNeill G, Proia P, Hauser S.L, Oksenberg J.R., Savettieri G. (2005) The HLA locus and multiple sclerosis in Sicily. Neurology 64:361-363.
6. Forte GI, Ragonese P, Salemi G., Scola L, Candore G, D'Amelio M, Crivello A, Di Benedetto N, Nuzzo D, Giacalone A, Lio D, Caruso C. (2006) Search for genetic factors associated with susceptibility to Multiple Sclerosis. Ann.New York Acad Sci 1067:264-269.
7 - Aridon P, Ragonese P, De Fusco M, Lo Coco D, Salemi G., Casari G, Savettieri G. (2007) Autosomal dominant hereditary spastic paraplegia: report of a large italian family with R581X spastin mutation. Neurol Sci. 28:171-174.
8 - Aridon P, Ragonese P, De Fusco M, Salemi G., Casari G, Savettieri G. (2008) Further evidence of genetic heterogeneity in familial essential tremor. Parkinsonism & Related Disorders. 14:15-18.
9 - Savettieri G, Annesi G, Civitelli D, Cirò Candiano IC, Salemi G, Ragonese P, Annesi F, Tarantino P, Terruso V, D'Amelio M, Quattrone A (2008) Identification of the novel D297fsX318 PINK1 mutation and phenotype variation in a family with early-onset Parkinson's disease. Parkinsonism Relat Disord.14:509-512.
10 - Salemi G, Gueli MC, D'Amelio M, Saia V, Mangiapane P, Aridon P, Ragonese P, Lupo I. (2009) Blood levels of homocysteine, cysteine, glutathione, folic acid, and vitamin B(12) in the acute phase of atherothrombotic stroke. Neurol Sci. 30:361-364.
11 - Proia P, Schiera G, Salemi G, Ragonese P, Savettieri G, Di Liegro I. (2009) Neuronal and BBB damage induced by sera from patients with secondary progressive multiple sclerosis. Int J Mol Med. 24:743-747.
12 - Salemi G, Gueli MC, Vitale F, Battaglieri F, Guglielmini E, Ragonese P, Trentacosti A, Massenti MF, Savettieri G, Bono A. (2010) Blood lipids, homocysteine, stress factors, and vitamins in clinically stable multiple sclerosis patients. Lipids Health Dis. 18;9:19.
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