Giuseppe Biamonti
e-mail: biamonti AT igm.cnr.it
affiliation: Istituto di Genetica Molecolare-CNR, Pavia
research area(s):
Course:
Genetics, Molecular and Cellular Biology
University/Istitution: Università di Pavia
University/Istitution: Università di Pavia
Education
1980 Degree in Biological Sciences - University of Pavia (110/110 with honours)
1986 PhD in Genetics and Molecular Biology University of Pavia
Professional Experience
1986-1987 Visiting scientist. Microbiology Department Cornell University Medical School (New York, USA)
1990 Visiting scientist. Virology Unit - Pasteur Institute, (Parigi, Francia)
2007- 2009 Director of the Project "Function, regulation and Evolution of the eukaryotic genomes" Department of Life Sciences, CNR
2007- 2009 Governing Council of the Italian Society of Biophysics and Molecular Biology
Since 2005 Member of the European Alternative Splicing Network (Eurasnet) within the FP6th
Position and Employment
1986-1995 CNR Researcher at the Institute of Biochemical and Evolutionary Genetics - CNR Pavia
1996- 2009 CNR Director of Research at the Institute of Molecular genetics - CNR Pavia
Since April 2009 Director of the Institute of Molecular Genetics - CNR, Pavia
1980 Degree in Biological Sciences - University of Pavia (110/110 with honours)
1986 PhD in Genetics and Molecular Biology University of Pavia
Professional Experience
1986-1987 Visiting scientist. Microbiology Department Cornell University Medical School (New York, USA)
1990 Visiting scientist. Virology Unit - Pasteur Institute, (Parigi, Francia)
2007- 2009 Director of the Project "Function, regulation and Evolution of the eukaryotic genomes" Department of Life Sciences, CNR
2007- 2009 Governing Council of the Italian Society of Biophysics and Molecular Biology
Since 2005 Member of the European Alternative Splicing Network (Eurasnet) within the FP6th
Position and Employment
1986-1995 CNR Researcher at the Institute of Biochemical and Evolutionary Genetics - CNR Pavia
1996- 2009 CNR Director of Research at the Institute of Molecular genetics - CNR Pavia
Since April 2009 Director of the Institute of Molecular Genetics - CNR, Pavia
The scientific activity of Giuseppe Biamonti focuses on the characterization of fundamental aspects of the biology of human cells such as DNA replication and RNA processing. Concerning the replication studies, he contributed to the identification and characterization of the human DNA replication origin associated with the Lamin B2 gene.
For what concerns the RNA metabolism, he showed that heat shock induces the transcriptional activation of large heterochromatic pericentric portions of the human genome formed by long tandem arrays of Satellite III repetitive DNA. Sat III RNAs remain associated with sites of transcription giving rise to a novel nuclear structure that he called "nuclear stress body".
More recently his interests focused on the analysis of alternative splicing deregulation in cancer progression. He showed that the level of splicing regulator SRSF1 controls the transition from epithelial to mesenchymal cell by modulating the splicing profile of the Ron proto-oncogene. He also showed that the level of SRSF1 transcripts are regulated at the post-transcriptional level through an alternative splicing events that directs the SRSF1 RNA to degradation via the Non-sense mediated RNA decay pathway.
Dr. Biamonti is co-author of 94 publications on international journals. H-index = 34
For what concerns the RNA metabolism, he showed that heat shock induces the transcriptional activation of large heterochromatic pericentric portions of the human genome formed by long tandem arrays of Satellite III repetitive DNA. Sat III RNAs remain associated with sites of transcription giving rise to a novel nuclear structure that he called "nuclear stress body".
More recently his interests focused on the analysis of alternative splicing deregulation in cancer progression. He showed that the level of splicing regulator SRSF1 controls the transition from epithelial to mesenchymal cell by modulating the splicing profile of the Ron proto-oncogene. He also showed that the level of SRSF1 transcripts are regulated at the post-transcriptional level through an alternative splicing events that directs the SRSF1 RNA to degradation via the Non-sense mediated RNA decay pathway.
Dr. Biamonti is co-author of 94 publications on international journals. H-index = 34
1: Vourc'h C, Biamonti G. Transcription of Satellite DNAs in Mammals. Prog Mol Subcell Biol. (2011) 51:95-118.
2: Valacca C, Bonomi S, Buratti E, Pedrotti S, Baralle FE, Sette C, Ghigna C, Biamonti G. Sam68 regulates EMT through alternative splicing-activated nonsense-mediated mRNA decay of the SF2/ASF proto-oncogene. J Cell Biol. (2010) 191: 87-99.
3: Ghigna C, De Toledo M, Bonomi S, Valacca C, Gallo S, Apicella M, Eperon I, Tazi J, Biamonti G. Pro-metastatic splicing of Ron proto-oncogene mRNA can be reversed: therapeutic potential of bifunctional oligonucleotides and indole derivatives. RNA Biol. (2010) 7: 495-503.
4: Marchetti L, Comelli L, D'Innocenzo B, Puzzi L, Luin S, Arosio D, Calvello M, Mendoza-Maldonado R, Peverali F, Trovato F, Riva S, Biamonti G, Abdurashidova G, Beltram F, Falaschi A. Homeotic proteins participate in the function of human-DNA replication origins. Nucleic Acids Res. (2010) 38: 8105-19.
5: Biamonti G, Vourc'h C. Nuclear stress bodies. Cold Spring Harb Perspect Biol. (2010) 2:295-310. Review.
6: Falaschi A, Abdurashidova G, Biamonti G. DNA replication, development and cancer: a homeotic connection? Crit Rev Biochem Mol Biol. (2010) 45: 14-22. Review.
7: Vago R, Leva V, Biamonti G, Montecucco A. DNA ligase I and Nbs1 proteins associate in a complex and colocalize at replication factories. Cell Cycle. (2009) 8: 2600-7.
8: Ghigna C, Valacca C, Biamonti G. Alternative splicing and tumor progression. Curr Genomics. (2008) 9: 556-70.
9: Dimitri P, Caizzi R, Giordano E, Carmela Accardo M, Lattanzi G, Biamonti G. Constitutive heterochromatin: a surprising variety of expressed sequences. Chromosoma. (2009) 118: 419-35.
10: Soza S, Leva V, Vago R, Ferrari G, Mazzini G, Biamonti G, Montecucco A. DNA ligase I deficiency leads to replication-dependent DNA damage and impacts cell morphology without blocking cell cycle progression. Mol Cell Biol. (2009) 29:2032-41.
11: Biamonti G, Caceres JF. Cellular stress and RNA splicing. Trends Biochem Sci. (2009) 34: 146-53. Review.
12: Valgardsdottir R, Chiodi I, Giordano M, Rossi A, Bazzini S, Ghigna C, Riva S, Biamonti G. Transcription of Satellite III non-coding RNAs is a general stress response in human cells. Nucleic Acids Res. (2008) 36: 423-34.
13: Lee YB, Colley S, Norman M, Biamonti G, Uney JB. SAFB re-distribution marks steps of the apoptotic process. Exp Cell Res. (2007) 313: 3914-23.
14: Falaschi A, Abdurashidova G, Sandoval O, Radulescu S, Biamonti G, Riva S. Molecular and structural transactions at human DNA replication origins. Cell Cycle. (2007) 6: 1705-12.
15: Abdurashidova G, Radulescu S, Sandoval O, Zahariev S, Danailov MB, Demidovich A, Santamaria L, Biamonti G, Riva S, Falaschi A. Functional interactions of DNA topoisomerases with a human replication origin. EMBO J. (2007) 26: 998-1009.
16: Montecucco A, Biamonti G. Cellular response to etoposide treatment. Cancer Lett. (2007) 252: 9-18. Review.
17: Rossi R, Lidonnici MR, Soza S, Biamonti G, Montecucco A. The dispersal of replication proteins after Etoposide treatment requires the cooperation of Nbs1 with the ataxia telangiectasia Rad3-related/Chk1 pathway. Cancer Res. (2006) 66: 1675-83.
18: Ghigna C, Giordano S, Shen H, Benvenuto F, Castiglioni F, Comoglio PM, Green MR, Riva S, Biamonti G. Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene. Mol Cell. (2005) 20: 881-90.
19: Valgardsdottir R, Chiodi I, Giordano M, Cobianchi F, Riva S, Biamonti G. Structural and functional characterization of noncoding repetitive RNAs transcribed in stressed human cells. Mol Biol Cell. (2005) 16: 2597-604.
20: Lidonnici MR, Rossi R, Paixão S, Mendoza-Maldonado R, Paolinelli R, Arcangeli C, Giacca M, Biamonti G, Montecucco A. Subnuclear distribution of the largest subunit of the human origin recognition complex during the cell cycle. J Cell Sci. (2004) 117: 5221-31.
21: Chiodi I, Corioni M, Giordano M, Valgardsdottir R, Ghigna C, Cobianchi F, Xu RM, Riva S, Biamonti G. RNA recognition motif 2 directs the recruitment of SF2/ASF to nuclear stress bodies. Nucleic Acids Res. (2004) 32: 4127-36.
22: Biamonti G. Nuclear stress bodies: a heterochromatin affair? Nat Rev Mol Cell Biol. (2004) 5: 493-8.
23: Shen H, Kan JL, Ghigna C, Biamonti G, Green MR. A single polypyrimidine tract binding protein (PTB) binding site mediates splicing inhibition at mouse IgM exons M1 and M2. RNA. (2004) 10:787-94.
24: Paixão S, Colaluca IN, Cubells M, Peverali FA, Destro A, Giadrossi S, Giacca M, Falaschi A, Riva S, Biamonti G. Modular structure of the human lamin B2 replicator. Mol Cell Biol. (2004) 24: 2958-67.
25: Rizzi N, Denegri M, Chiodi I, Corioni M, Valgardsdottir R, Cobianchi F, Riva S, Biamonti G. Transcriptional activation of a constitutive heterochromatic domain of the human genome in response to heat shock. Mol Biol Cell. (2004) 15: 543-51.
2: Valacca C, Bonomi S, Buratti E, Pedrotti S, Baralle FE, Sette C, Ghigna C, Biamonti G. Sam68 regulates EMT through alternative splicing-activated nonsense-mediated mRNA decay of the SF2/ASF proto-oncogene. J Cell Biol. (2010) 191: 87-99.
3: Ghigna C, De Toledo M, Bonomi S, Valacca C, Gallo S, Apicella M, Eperon I, Tazi J, Biamonti G. Pro-metastatic splicing of Ron proto-oncogene mRNA can be reversed: therapeutic potential of bifunctional oligonucleotides and indole derivatives. RNA Biol. (2010) 7: 495-503.
4: Marchetti L, Comelli L, D'Innocenzo B, Puzzi L, Luin S, Arosio D, Calvello M, Mendoza-Maldonado R, Peverali F, Trovato F, Riva S, Biamonti G, Abdurashidova G, Beltram F, Falaschi A. Homeotic proteins participate in the function of human-DNA replication origins. Nucleic Acids Res. (2010) 38: 8105-19.
5: Biamonti G, Vourc'h C. Nuclear stress bodies. Cold Spring Harb Perspect Biol. (2010) 2:295-310. Review.
6: Falaschi A, Abdurashidova G, Biamonti G. DNA replication, development and cancer: a homeotic connection? Crit Rev Biochem Mol Biol. (2010) 45: 14-22. Review.
7: Vago R, Leva V, Biamonti G, Montecucco A. DNA ligase I and Nbs1 proteins associate in a complex and colocalize at replication factories. Cell Cycle. (2009) 8: 2600-7.
8: Ghigna C, Valacca C, Biamonti G. Alternative splicing and tumor progression. Curr Genomics. (2008) 9: 556-70.
9: Dimitri P, Caizzi R, Giordano E, Carmela Accardo M, Lattanzi G, Biamonti G. Constitutive heterochromatin: a surprising variety of expressed sequences. Chromosoma. (2009) 118: 419-35.
10: Soza S, Leva V, Vago R, Ferrari G, Mazzini G, Biamonti G, Montecucco A. DNA ligase I deficiency leads to replication-dependent DNA damage and impacts cell morphology without blocking cell cycle progression. Mol Cell Biol. (2009) 29:2032-41.
11: Biamonti G, Caceres JF. Cellular stress and RNA splicing. Trends Biochem Sci. (2009) 34: 146-53. Review.
12: Valgardsdottir R, Chiodi I, Giordano M, Rossi A, Bazzini S, Ghigna C, Riva S, Biamonti G. Transcription of Satellite III non-coding RNAs is a general stress response in human cells. Nucleic Acids Res. (2008) 36: 423-34.
13: Lee YB, Colley S, Norman M, Biamonti G, Uney JB. SAFB re-distribution marks steps of the apoptotic process. Exp Cell Res. (2007) 313: 3914-23.
14: Falaschi A, Abdurashidova G, Sandoval O, Radulescu S, Biamonti G, Riva S. Molecular and structural transactions at human DNA replication origins. Cell Cycle. (2007) 6: 1705-12.
15: Abdurashidova G, Radulescu S, Sandoval O, Zahariev S, Danailov MB, Demidovich A, Santamaria L, Biamonti G, Riva S, Falaschi A. Functional interactions of DNA topoisomerases with a human replication origin. EMBO J. (2007) 26: 998-1009.
16: Montecucco A, Biamonti G. Cellular response to etoposide treatment. Cancer Lett. (2007) 252: 9-18. Review.
17: Rossi R, Lidonnici MR, Soza S, Biamonti G, Montecucco A. The dispersal of replication proteins after Etoposide treatment requires the cooperation of Nbs1 with the ataxia telangiectasia Rad3-related/Chk1 pathway. Cancer Res. (2006) 66: 1675-83.
18: Ghigna C, Giordano S, Shen H, Benvenuto F, Castiglioni F, Comoglio PM, Green MR, Riva S, Biamonti G. Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene. Mol Cell. (2005) 20: 881-90.
19: Valgardsdottir R, Chiodi I, Giordano M, Cobianchi F, Riva S, Biamonti G. Structural and functional characterization of noncoding repetitive RNAs transcribed in stressed human cells. Mol Biol Cell. (2005) 16: 2597-604.
20: Lidonnici MR, Rossi R, Paixão S, Mendoza-Maldonado R, Paolinelli R, Arcangeli C, Giacca M, Biamonti G, Montecucco A. Subnuclear distribution of the largest subunit of the human origin recognition complex during the cell cycle. J Cell Sci. (2004) 117: 5221-31.
21: Chiodi I, Corioni M, Giordano M, Valgardsdottir R, Ghigna C, Cobianchi F, Xu RM, Riva S, Biamonti G. RNA recognition motif 2 directs the recruitment of SF2/ASF to nuclear stress bodies. Nucleic Acids Res. (2004) 32: 4127-36.
22: Biamonti G. Nuclear stress bodies: a heterochromatin affair? Nat Rev Mol Cell Biol. (2004) 5: 493-8.
23: Shen H, Kan JL, Ghigna C, Biamonti G, Green MR. A single polypyrimidine tract binding protein (PTB) binding site mediates splicing inhibition at mouse IgM exons M1 and M2. RNA. (2004) 10:787-94.
24: Paixão S, Colaluca IN, Cubells M, Peverali FA, Destro A, Giadrossi S, Giacca M, Falaschi A, Riva S, Biamonti G. Modular structure of the human lamin B2 replicator. Mol Cell Biol. (2004) 24: 2958-67.
25: Rizzi N, Denegri M, Chiodi I, Corioni M, Valgardsdottir R, Cobianchi F, Riva S, Biamonti G. Transcriptional activation of a constitutive heterochromatic domain of the human genome in response to heat shock. Mol Biol Cell. (2004) 15: 543-51.
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