Education and training
- 1975 Degree in Biological Sciences, University of Modena, Italy
- 1978 Speciality in Biochemistry and Clinical Chemistry, University of Parma, Italy
- 1984 Speciality in Human Nutrition, University of Modena, Italy
- 1980 - 1984 Research fellow at the Institute of General Pathology, University of
Modena, Italy.

Employment and Research Experience
1984 - 1987: Research Technician, Laboratory of Lipoprotein Biochemistry, Institute
of General Pathology, University of Modena.
1987 - 1998: Chief Research Technician, Laboratory of Lipoprotein Biochemistry and
Pathophysiology of Dyslipoproteinemias, Institute of General Pathology, University of
Modena.
1998 - 2010: Associate Professor of General Pathology, Faculty of Pharmacy,
Department of Biomedical Sciences, Section of General Pathology, University of
Modena and Reggio Emilia, Italy
2010- present: Full Professor of General Pathology, Faculty of Pharmacy,
Department of Biomedical Sciences, Section of General Pathology, University of
Modena and Reggio Emilia, Italy

Main research areas

From late 70’ up to now the main focus of the research activity has been the metabolism of lipids and lipoproteins in humans and experimental animal models. Over the years the research interests of the laboratory has focussed on two main topics: i) the biochemistry and pathophysiology of plasma lipoproteins; ii) the molecular genetics and molecular pathology of inherited disorders of plasma lipoproteins and cholesterol metabolism.

1: Noto D, Cefalù AB, Barraco G, Fayer F, Min√† M, Yue P, Tarugi P, Schonfeld G, Averna MR.
Plasma non-cholesterol sterols in primary hypobetalipoproteinemia.
Atherosclerosis. 2011 Jun;216(2):409-13.

2: Calandra S, Tarugi P, Bertolini S.
Altered mRNA splicing in lipoprotein disorders.
Curr Opin Lipidol. 2011 Apr;22(2):93-9.

3: Uslu N, Gurakan F, Yuce A, Demir H, Tarugi P.
Abetalipoproteinemia in an infant with severe clinical phenotype and a novel mutation.
Turk J Pediatr. 2010 Jan-Feb;52(1):73-7.

4: Zhong S, Magnolo AL, Sundaram M, Zhou H, Yao EF, Di Leo E, Loria P, Wang S, Bamji-Mirza M, Wang L, McKnight CJ, Figeys D, Wang Y, Tarugi P, Yao Z.
Nonsynonymous mutations within APOB in human familial hypobetalipoproteinemia: evidence for feedback inhibition of lipogenesis and postendoplasmic reticulum degradation of apolipoprotein B.
J Biol Chem. 2010 Feb 26;285(9):6453-64.

5: Pisciotta L, Tarugi P, Borrini C, Bellocchio A, Fresa R, Guerra D, Quaglino D, Ronchetti I, Calandra S, Bertolini S.
Pseudoxanthoma elasticum and familial hypercholesterolemia: a deleterious combination of cardiovascular risk factors.
Atherosclerosis. 2010 May;210(1):173-6.

6: Cefalù AB, Noto D, Arpi ML, Yin F, Spina R, Hilden H, Barbagallo CM, Carroccio A, Tarugi P, Squatrito S, Vigneri R, Taskinen MR, Piterfy M, Averna MR.
Novel LMF1 nonsense mutation in a patient with severe hypertriglyceridemia.
J Clin Endocrinol Metab. 2009 Nov;94(11):4584-90. Epub 2009 Oct 9. Erratum in: J Clin
Endocrinol Metab. 2010 Jan;95(1):465.

7: Cariou B, Ouguerram K, Zaïr Y, Guerois R, Langhi C, Kourimate S, Benoit I, Le May C, Gayet C, Belabbas K, Dufernez F, Chétiveaux M, Tarugi P, Krempf M, Benlian P, Costet P.
PCSK9 dominant negative mutant results in increased LDL catabolic rate and familial hypobetalipoproteinemia.
Arterioscler Thromb Vasc Biol. 2009 Dec;29(12):2191-7.

8: Fancello T, Dardis A, Rosano C, Tarugi P, Tappino B, Zampieri S, Pinotti E, Corsolini F, Fecarotta S, D'Amico A, Di Rocco M, Uziel G, Calandra S, Bembi B, Filocamo M.
Molecular analysis of NPC1 and NPC2 gene in 34 Niemann-Pick C Italian patients: identification and structural modeling of novel mutations.
Neurogenetics. 2009 Jul;10(3):229-39.

9: Calabresi L, Nilsson P, Pinotti E, Gomaraschi M, Favari E, Adorni MP, Bernini F, Sirtori CR, Calandra S, Franceschini G, Tarugi P.
A novel homozygous mutation in CETP gene as a cause of CETP deficiency in a Caucasian kindred.
Atherosclerosis. 2009 Aug;205(2):506-11.

10: Di Leo E, Magnolo L, Pinotti E, Martini S, Cortella I, Vitturi N, Rabacchi C, Wunsch A, Pucci F, Bertolini S, Calandra S, Tarugi P.
Functional analysis of two novel splice site mutations of APOB gene in familial hypobetalipoproteinemia.
Mol Genet Metab. 2009 Feb;96(2):66-72.

No projects are available to students for the current accademic year.