Education:
1990 Trento – University of Trento - Degree in Physics

Employment
• 16/04/2009 to presently: Senior Researcher of CNR
• Since 09/07/2004 – Head of the Unit at Trento of the Institute of Biophysics CNR
• 14/08/2003 to 15/04/2009: Senior Researcher of the Bruno Kessler Foundation (former ITC - Istituto Trentino di Cultura) assigned to the IBF-CNR Unit at Trento
• 01/04/1996 – 13/08/2003: appointed Researcher of the ITC assigned to CNR - Centre for Physics of the Aggregated States (CeFSA)
• 01/08/1994 – 31/03/1996: recipient of a Grant from the Department of Physics, University of Trento
• 01/08/1993 – 31/07/1994: recipient of a Fellowship from the National Council of Researches at the CeFSA
• 01/06/1992 – 30/06/1993: recipient of a Fellowship from the National Institute for the Physics of Matter at the CeFSA
• 01/01/1991 – 31/05/1992: recipient of a Fellowship at the Institute for Scientific and Technological Research

Refereeing: I am referee for many leading journals in the field of biochemistry and biophysics: Biochemical Journal (UK), Biophysical Journal (USA) Biochemistry USA, Biochimica Biophysica Acta (Holland), FEBS letters (Switzerland), Toxicon (UK), FEMS Microbiology letters (UK), Antimicrobial Agents and Chemotherapy (USA), Molecular Microbiology, Toxicology. I am regular referee for applications to International Foundation for Science.

Memberships: I am a member of the Biophysical Society (USA), of the International Society of Toxinology (IST), of the Italian Society for Pure and Applied Biophysics (SIBPA) and of the European Biophysical Societies Association EBSA.

h-index=21 (see http://www.researcherid.com/rid/A-6218-2010)

My collaborators and myself, have developed a thorough biophysical and biochemical approach to investigate structural and functional aspects of the interaction of membrane-active molecules with the lipid film. A large portion of my work has been dedicated to protein-protein and protein-lipid interaction, in particular to the mechanism of action of membrane-damaging toxins of bacterial or animal origin. However, my interest goes also to many other substances that are relevant for human health. I have been working with small antibiotics (e.g. lipocyclopeptides and synthetic peptides), with natural non-protein biopolymers (such as poly alkylpyridinium ions), or peptides causing misfolding diseases (beta-amyloid, alpha-syniclein). I have published more than 50 articles in international refereed journals, and contributed 9 chapters to multiauthored books.

1.Viero, G., Cunaccia, R., Keller, D., Werner, S., Monteil, H., Prévost, G., Menestrina, G., and Dalla Serra, M. 2005. Homologous versus heterologous interactions in the pore of bicomponent staphylococcal -hemolysins. 2006. Biochem.J. 394:217-225
2.Stellato,F., G.Menestrina, M.Dalla Serra, C.Potrich, R.Tomazzolli, W.Meyer-Klaucke, and S.Morante. Metal binding in amyloids beta peptides shows intra- and inter-peptide coordination modes. 2006. Eur.Biophys.J. 35:340-351.
3.Drechsler, A., Potrich, C., Sabo, J. K., Frisanco, M., Guella, G., Dalla Serra, M., Anderluh, G., Separovic, F., and Norton, R. S. Structure and activity of the N-terminal region of the eukaryotic cytolysin equinatoxin II. 2006. Biochemistry 45:1818-1828.
4.Tomazzolli, R., Dalla Serra, M., Bellisola, G., Colombatti, M., Guella, G. A fluorescence-based assay for the reductase activity of protein disulfide isomerase. 2006 Anal.Biochem. 350:105-112.
5.A.J. García-Sáez, M. Coraiola, M. Dalla Serra, I. Mingarro, P. Muller, J. Salgado. Peptides corresponding to helices 5 and 6 of Bax can independently form large lipid pores. 2006 FEBS J. 273:971-981.
6.Baba-Moussa,L., S.Werner, M.Coraiola, D.A.Colin, D.Keller, A.Sanni, M.Dalla Serra, H.Monteil, and G.Prévost. 2006. Site directed mutagenesis to assess the binding capacity of class S protein of Staphylococcus aureus leucotoxins to the surface of polymorphonuclear cells. J.Biomed.Biotech. Article ID 80101:1-8.
7.Joubert,O., G.Viero, D.Keller, E.Martinez, D.A.Colin, H.Monteil, L.Mourey, M.Dalla Serra, and G.Prévost. 2006. Engineered covalent leucotoxin heterodimers form functional pores: insights into S-F interactions. Biochem.J. 396:381-389
8.Bonini, F., Traini, R., Comper, F., Fracasso, G., Tomazzolli, R., Dalla Serra, M., and Colombatti, M. N-terminal deletion affects catalytic activity of saporin toxin. 2006. J.Cell.Biochem. 98:1130-1139.
9.Lo Cantore, P., Lazzaroni, S., Coraiola, M., Dalla Serra, M., Cafarchia, C., Evidente, A. and Iacobellis, N. S. 2006. Biological Characterisation of WLIP produced by Pseudomonas reactans strain NCPPB1311. Mol.Plant-Microbe Interact. 19:1113-1120.
10.Coraiola, M., Lo Cantore, P., Lazzaroni, S., Evidente, A., Iacobellis, N. S. and Dalla Serra, M. 2006. Tolaasin I and WLIP, Lipodepsipeptides from Pseudomonas tolaasii and P. "reactans", permeabilize model membranes. Biochim.Biophys.Acta 1758:1713-1722.
11.Joubert,O., J.Voegelin, V.Guillet, S.Tranier, S.Werner, D.A.Colin, M.Dalla Serra, D.Keller, H.Monteil, L.Mourey, and G.Prévost. 2007. Distinction between pore assembly by staphylococcal -toxin versus leucotoxins. J.Biomed.Biotechnol. ID 25935: 1-13
12.Kristan,K., G.Viero, P.Macek, M.Dalla Serra*, and G.Anderluh*. 2007. The Equinatoxin N-Terminus is transferred across planar bilayers and helps to stabilise the transmembrane pore. FEBS J 274:539-550. (*Dalla Serra and Anderluh are corresponding authors)
13.Sujak, A., Gagos, M., Dalla Serra, M., and Gruszecki, W. I. 2007. Organization of two-component monomolecular layers formed with dipalmitoylphosphatidylcholine and carotenoid pigment canthaxanthin. Mol.Membr.Biol. 24: 431-441.
14.Coraiola,M., R.Paletti, A.Fiore, V.Fogliano, and M.Dalla Serra. 2008. Fuscopeptins, antimicrobial lipodepsipeptides from Pseudomonas fuscovaginae, are channel forming peptides active on biological and model membranes. J.Pep.Sci. 4:496-502.
15.Viero,G., A.Gropuzzo, O.Joubert, D.Keller, G.Prévost, and M.Dalla Serra. 2008. A molecular pin to study the dynamic of -barrel formation in Pore Forming Toxins on erythrocytes: a sliding model. Cell. Mol. Life Sci.65:312-323
16.Minicozzi,V., F.Stellato, M.Comai, M.Dalla Serra, C.Potrich, W.Meyer-Klaucke, and S.Morante. 2008. Identifying the minimal Cu and Zn binding site sequence in amyloid beta peptides. J Biol Chem 283:10784-10792
17.Dalla Serra,M., O.Cirioni, R.M.Vitale, G.Renzone, M.Coraiola, A.Giacometti, C.Potrich, E.Baroni, G.Guella, M.Sanseverino, S.De Luca, G.Scalise, P.Amodeo, and A.Scaloni. 2008. Structural features of distinctin affecting peptide biological and biochemical properties. Biochemistry 47:7888-7899.
18.Gagos,M., M.Herec, M.Arczewska, G.Czernel, M.Dalla Serra, and W.I.Gruszecki. 2008. Anomalously high aggregation level of the polyene antibiotic amphotericin B in acidic medium: Implication for the pharmacological action. Biophys. Chem. 136:44-49.
19.Rabzelj,S., G.Viero, I.Gutierrez-Aguirre, V.Turk, M.Dalla Serra, G.Anderluh, and E.Zerovnik. 2008. Interaction with model membranes and pore formation by human stefin B; studying the native and prefibrillar states. FEBS J 275:2455-2466.
20.Potrich,C., H.Bastiani, D.A.Colin, S.Huck, G.Prévost, and M.Dalla Serra. 2009. The influence of cholesterol and cone-shaped lipids in Staphylococcus aureus gamma-hemolysins pore formation. J. Membr. Biol. 227:13-24.
21.Kristan,K., G.Viero, M.Dalla Serra, P.Macek, and G.Anderluh. 2009. Molecular mechanism of pore formation by actinoporins. Toxicon 54:1125-1134.

No projects are available to students for the current accademic year.