Actual Position: Associate Professor in Organic Chemistry (SSD CHIM06), University of Trento

Education and carrier
Master degree in Chemistry, University of Bologna , advisor: prof. A. Umani-Ronchi, 1983; grant from Provincia Autonoma di Trento for research activity in Organic chemistry , 1983-1986; researcher in Organic Chemistry, university of Trento, 1987-2006.

Assignments:
Head of the laboratory of Bioorganic Chemistry, Dept Physics( from 2009), vice-coordinator of the international school of Biomolecular Sciences (from 2009), university delegate on workers’ safety, referential person of the Faculty of Sciences with secondary schools on life sciences.

Professional Membership:
Italian Chemical Society, Consorzio nazionale Interuniversitari per le scienze del mare (CONISMA), Consorzio nazionale interuniversitario per le scienze fisiche della materia (CNISM).

Teaching Activity:
University of Trento: Organic Chemistry (course in Biotechnology, 2009-2011 and previously for degree in Physics ), Special Methods in Bioorganic Chemistry (course in Biotechnology, 2010); Chemistry for Bioinformatics ( Master degree in Informatics, 2006-2011), General chemistry with laboratory (course in Physics, until 2008), Laboratory Safety (PhD course in Biomolecular Sciences), 201-2011; University of Verona: Medicinal and pharmaceutical technology ( 2009-2011).

In the field of structural and synthetic bioorganic chemistry and based on more than 25-year expertise in the isolation and structural elucidation, associated to chemical modifications and chiral total synthesis of natural compounds from marine organisms with potential bioactivity. Recent additional topics are related to antitumoral and antiviral drug design , studies of supramolecular systems of bioactive molecules included into cyclodextrins, application of mass spectrometry to the analysis and reactivity investigation of bioactive molecules, structural characterization of products from catalytic pyrolysis of biomass and cellulose and their application as chiral building blocks in peptidomimetics and synthesis of bioactive molecules.

1) I. Mancini, A. Defant, T. Mesari, F. Potocnik c, U.Batista, G. Guella, T.Turk , K. Sepcic, “Fatty acid composition of common barbel (Barbus barbus) roe andevaluation of its haemolytic and cytotoxic activities” Toxicon, 2011, 1-6, DOI: 10.1016/j.toxicon.2011.04.004
2) V.Crupi, G.Guella, D. Majolino, I. Mancini, A. Paciaroni, B. Rossi, V. Venuti, P. Verrocchio, G. Viliani, “Effect of the chiral discrimination on the vibrational properties of (R)-, (S)- and (R, S)-ibuprofen/methyl-.beta.-cyclodextrin inclusion complexes”. Philosophical Magazine 2011, 91, 1776-1785.
3) V. Tamboli, A. Defant, I. Mancini*, P. Tosi ”A study of resveratrol-copper complexes by electrospray ionization mass spectrometry and density functional theory calculations”. Rapid Communications in Mass Spectrometry 2011, 25, 526-532.
4) A. Defant, I. Mancini*, C.Torri, D. Malferrari, D. Fabbri, “An efficient route towards a new branched tetrahydrofurane .delta.-sugar amino acid from a pyrolysis product of cellulose”. Amino Acids 2011, 40, 633-640.
5) A. Defant, B. Rossi, G. Viliani, G. Guella, I. Mancini*, “Metal-assisted regioselectivity in nucleophilic substitutions: a study by Raman spectroscopy and density functional theory calculations” Journal of Raman Spectroscopy, 2010, 41, 1398-1403.
6) V. Crupi, D. Majolino, V. Venuti, G. Guella, I. Mancini, B. Rossi, P. Verrocchio, G. Viliani, R. Stancanelli, “Temperature Effect on the Vibrational Dynamics of Cyclodextrin Inclusion Complexes: Investigation by FTIR-ATR Spectroscopy and Numerical Simulation”. Journal of Physical Chemistry A 2010, 114, 6811-6817.
7) G. Guella, R. Frassanito, I. Mancini, T. Sandron, L. Modeo, F. Verni, F. Dini, G. Petroni,. “Keronopsamides, a New Class of Pigments from Marine Ciliates” European Journal of Organic Chemistry 2010, 3, 427-434.
8) V. Crupi, G. Guella, D. Majolino, I. Mancini, B. Rossi, R. Stancanelli, V. Venuti, P.Verrocchio, G. Viliani, “T-dependence of the vibrational dynamics of ibuprofen/diME-β -cyclodextrin in solid state: A FT-IR spectral and quantum chemical study” Journal of Molecular Structure, 2010, 972, 75-80.
9) W.E. Houssen , Z. Lu, R.A. Edrada-Ebel, C. Chatzi, S. J. Tucke, K. Sepčić, T. Turk, A. Zovko, S. Shen, I. Mancini*, R.H. Scott, M. Jaspars* “Chemical synthesis and biological activities of 3-alkylpyridinium polymeric analogues of marine toxins”, J Chem Biol 2010, 3, 113–125.
9) G. Guella, I.Mancini, G. Mariotto, B. Rossi, G. Viliani “Vibrational analysis as a powerful tool in structure elucidation ofpolyarsenicals: a DFT-based investigation of arsenicin A”. Physical Chemistry Chemical Physics, 2009, 11, 2420-2427.
10) B. Rossi, P. Verrocchio, G. Viliani, I. Mancini, G. Guella, E. Rigo, G. Scarduelli, G. Mariotto, “Vibrational properties of ibuprofen-cyclodextrin inclusion complexes investigated by Raman scattering and numerical simulation”. Journal of Raman Spectroscopy 2009, 40, 453-458.
11) A. Defant, G. Guella, I. Mancini*, ”Synthesis and in-vitro cytotoxicity evaluation of novel naphtindolizinedione derivatives, Part II: improved activity for aza-analogues”. Archiv der Pharmazie 2009, 342, 80-86.
12) G. Scarduelli, G. Guella, I. Mancini, G. Dilecce, S. De Benedictis, P. Tosi, “Methane oligomerization in a dielectric barrier discharge at atmospheric pressure”. Plasma Processes and Polymers 2009, 6, 27-33.
13) A. Defant, G.Guella, I. Mancini*, "Microwave-assisted multi-component synthesis of aza- and diaza-, benzo- and dibenzofluorenedione derivatives ". Synth. Commun. 2008, 38, 3003-3016.
14) R. Frassanito, M. Cantonati, G. Flaimm, I.Mancini, G. Guella “A new method for the identification and the structural characterization of carotenoid esters in freshwater microorganisms by liquid chromatography-electrospray tandem mass spectrometry” Rapid Commun. Mass Spectrom. 2008, 22, 3531-3539.
15) P. Taehtinen, G. Saielli, G. Guella, I. Mancini, A. Bagno, “Computational NMR spectroscopy of organoarsenicals and the natural polyarsenic compound arsenicin A”. Chemistry--A European Journal 2008, 14, 10445-10452.
16) D. Fabbri, C.Torri, I.Mancini, "Pyrolysis of cellulose catalysed by nanopowder metal oxides: production andcharacterisation of a chiral hydroxylactone and its role as building block". Green Chemistry, 2007, 9, 1374-1379.
17) D. J. Koss, K. P. Hindley, K. C. David, I. Mancini, G. Guella, K. Sepčić, G. Riedel, B. Platt, R.H. Scott, “A comparative study of the actions of alkylpyridinium salts from a marine sponge and related synthetic compounds in rat cultured hippocampal neurons” BMC Pharmacology, 2007, 7 , 1-17.
18) A. Defant, G. Guella, I.Mancini* “ Synthesis and in vitro cytotoxicity of novel naphthindolizinedione derivatives“Archive der Pharmazie. Chemistry in Life Sciences, 2007, 340, 147-153.

No projects are available to students for the current accademic year.